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English, Finish, Swiss and German scientists have put the finishing touches on a recent study that was published in 2007, stating that (My Reductil) sibutramine treatment should be offered as a part of a long term integrated therapeutic approach, including dietary and behavioral modification as well as increased exercise.

Clinical trials have demonstrated that (My Reductil) sibutramine can produce and sustain weight reduction in subjects who have failed to lose and maintain weight loss through diet and exercise alone. That study shows that benifits associated with (My Reductil) sibutramine treatment could be considered as a viable option for pharmacotherapy alongside  diet and exercise.

They estimated the costs and quality of life benefits directly associated with the reduced incidences of coronary heart disease and diabetes. The health costs directly attributable to obesity have been estimated to be as high as  8% of the overall health budgets.

That 54 week study conducted in a primary care setting, explored the effect of a standardized non pharmacological treatment program and (My Reductil) sibutramine treatment or placebo on long term weight reduction in obese subjects with body mass index  equal to or greater than 30 kilograms / square meters. The mean weight loss at the end of study was 8.1 plus or minus 8.2 kg for the (My Reductil) sibutramine group versus 5.1 plus or minus 6.5 kg for patients receiving placebo.

Responders to treatment experienced a mean weight loss of 12 kg at 12 months compared with 6.5 kg for the placebo group. Patients who withdrew because of lack of efficacy returned to their natural history levels immediately, while patients responding to treatment, and those in the placebo arm , reached their original weights  by months 57 and 39 respectively.

The results also showed a significant reduction in coronary heart disease risk after (My Reductil) sibutramine. Also, published evidence suggests that a reduction in body mass index (BMI) from 42 kg/sq. meters to 33 kg/sq. meters give a corresponding reduction in diabetes incidences of 6.1% over a 2-year period.

For a group of 1000 patients, the total number of coronary heart disease events avoided through 12 months of sibutramine treatment is estimated to range from 1.96 for the UK evaluation to 4.08 for the Swiss evaluation. The model also estimates that the number of cases of diabetes that will be avoided will be in the region of 3 for the German evaluation to 3.28 for the Swiss evaluation.

So, the above facts demonstrate that 1 year of (My Reductil) sibutramine 10 or 15 mg tablets treatment  is cost-effective  compared with diet and life style interventions currently received by obese patients in all the countries.

We all now that (My Reductil) sibutramine has produced a dose-related improvement in weight reduction of patients on a restricted diet by a dual action: First,  it reduces food intake by enhancing satiety, and second, it also increases energy expenditure by enhancing metabolic rate, that is the rate by which our body burns our calories.

And since anyone’s ability to try (My Reductil) sibutramine can extend for a year or more, so it is therefore likely that alcohol will be taken concomittantly, so I think it is out of relevant practical importance that I consider writing about the dynamics of (My Reductil) sibutramine when given in combination with alcohol.

In 1991, a group of english scientists from Cognitive Drug Research Limited, investigated the effects of sibutramine, the active ingredient of (My Reductil) in combination alcohol on 20 healthy volunteers.

All 20 volunteers completed 4 (study days) or (treatment periods) of 1 day separated by a minimum of 7 day wash-out period. The volunteers were assigned randomly to receive oral doses of each of 4 treatment combinations on a single occasion. In the morning of the 4 study days, volunteers received either two sibutramine 10 mg capsules plus 0.5 g/kg alcohol, two sibutramine 10 mg capsules plus placebo alcohol, two placebo capsules plus 0.5 g/kg alcohol, or two placebo capsules plus placebo alcohol. The alcohol was diluted in ginger ale, the glass was covered with cling-film, and the mixture (400 ml) was administered through a straw 2 hours after ingestion of the study capsules, so that the peak alcohol concentration would coincide with the peak sibutramine concentration at 3 hours. The volunteers received a standardized breakfast 30 minutes after taking their sibutramine capsules. Lunch was provided following the 4.5 hour cognitive test session.

Assessments were made before, and 3, 4.5, 6, and 10 hours after sibutramine administration. The assessments were performed in the following sequence: blood alcohol concentration, cognitive performance tests ( like the ones they use to test attention, alertness, and memory ), and adverse effects recordings. I’ll cut to the chase here and mention the results of that interesting experiment.

As for the blood alcohol levels, as expected, the average breath alcohol concentration was greatest at the 3 hour assessment. The mean alcohol level following alcohol alone at this time was 53.2 mg/dl. this declined steadily thereafter. At 4.5 hours, it was 36.5 mg/dl, at 6 hours, it was 8.1 mg/dl, and was not detectable by 10 hours.

As for the results of the cognitive tests, the overall picture was that sibutramine, the active ingredient of (My Reductil) improved the speed of carrying out the majority of these tests, in contrast to alcohol which impaired speech. Sibutramine also reduced some errors in visual tracking tasks and reduced body sway. Alcohol impaired picture recognition sensitivity, the speed of word recognition, and increased body sway. Subjective alertness was also lowered following alcohol. There was statistically significant interaction effect shown by the picture recognition sensitivity, and the performance  was less impaired when alcohol was given in combination with sibutramine.

The number of adverse effects reported was highest in the treatment groups in which alcohol was taken. In the alcohol plus placebo treatment group, 16 (80%) volunteers reported 25 events, and in the sibutramine plus alcohol treatment groups, 12 (60%) volunteers reported 18 events. Of these reports, the highest number were in the “nervous” category including very mild weakness, dizziness, or stupor that no volunteer required withdrawal from the study because of such adverse effects. Following sibutramine and placebo, five volunteers (25%) reported 8 events, and in the placebo group, five volunteers (26%) reported 5 events.

So, to conclude, alcohol has long been found to disrupt attention, verbal and non-verbal aspects of memory, to increase body sway, and to lower alertness. Co-administration of sibutramine, the active ingredient of (My Reductil) with alcohol reduced the impairments observed when alcohol was administered alone. In fact, sibutramine improved performance on several tests, and the improvements with sibutramine were generally comparable with the impairments produced by alcohol.

The real reason why I posted this article was to ask the questionwhich I made the headline for my post : Why sibutramine, the active ingredient of (My Reductil)  hasn’t been used sice 1991 - in addition to its weight reduction capability -  to reduce the cognitive impairments done by drinking alcohol ?? It somhow works, but the authers mention at the end of this study that  the data given hasn’t yet justified that use, but I really think it may be a whole new locked  door for sibutramine, the active ingredient of (My Reductil)to try to unlock.

For any of you readers out there who wants the full text article of this study, e-mail me, and I’ll  be happy to send it to you FREE OF CHARGE.

My e-mail is : 

amebied@gmail.com

“ My Reductil “ What really works …

Mechanisms for regulating food intake are still not clearly established. That the hypothalamus plays a part in these mechanisms, however, seems certain. Numerous studies seem to indicate that a cluster of neurons in the lateral hypothalamus function as an appetite center (meaning that impulses from them bring about increased appetite). Other data suggest that a group of neurons in the ventral medial nucleus of the hypothalamus functions as a satiety center (meaning that impulses from these neurons decrease appetite so that we feel sated, or satisfied. What acts directly on these centers to stimulate or depress them is still a matter of theory rather than a fact.

One theory ( the thermostat theory ) holds that it is the temperature of the blood circulating to the hypothalamus that influences the centers. A moderate decrease in blood temperature stimulates the appetite center (and inhibits the satiety center). Result : the individual has an appetite, wants to eat, and probably does. An increase in blood temperature produces the opposite effect, a depressed appetite (anorexia). One well-known instance of this is the loss of appetite in persons who have a fever.

Another theory ( the glucostat theory ) says that it is the glucose concentration and rate of glucose use that influences the hypothalamic feeding centers. A low blood glucose concentration and rate of glucose use stimulates the appetite center, whereas high blood glucose concentration inhibits it.

The use of (My Reductil) as a drug for weight loss is highly linked to the body’s own appetite control mechanisms, where it suppresses appetite an stimulates the body to use its own energy resources.

The active ingredient of (My Reductil) is sibutramine. Sibutramine was originally developed as an antidepressant ( fights depression ), and it exerts its effect by helping two other substances: noradrenaline and serotonin stay as long as possible in the brain. Noradrenaline is the hormone of stress. It gushes through our blood at times of fight or fear moments to help us use all our bodily capabilities to either fight or run away from the stress at hand. I don’t think anyone who might be reading that article ever had the desire to eat when faced by any threat. Serotonin is a local hormone that controls the release of another local hormone called leptin whose receptors are in the brain and their activation by leptin inhibits impulses that increase appetite, and stimulates impulses that decrease appetite.

This drug is rapidly absorbed from the gut, and it is extensively metabolized ( broken down ) in the liver, and its resulting substances have a half life ( time for the body to breakdown half of the substance ) is 14 – 16 hours, and is responsible for its effects. That’s why (My Reductil) should be taken early in the morning, so that it doesn’t make you awake and disturb your sleeping time, especially on the first day of taking the drug.

(My Reductil) shouldn’t be taken carelessly by patients. It should be prescribed only for people with Body Mass Index (BMI) of 27 or more who have other heart or blood vessel risk factors, or 30 or more in their absence. It should be stopped if weight lost after 3 months is less than 5% of the initial weight. It should be stopped also if weight lost stabilizes at less than 5% of the initial weight thereafter ( despite increase in concentration of My Reductil ), or if users regain more than 3 kg after previous weight loss. It should not be given for more than 1 year.

If one wanna calculate one’s own BMI, Divide your weight in kilograms by the square of your height in meters. So for example, if your weight is 115 kg, and your height is 180 centimeters ( i.e. 1.8 meters ), so your BMI can be calculated as 115/(1.8)² = 115/3.24 = 35.4, so, if you have no other contraindications to use (My Reductil), you’ll definitely be able to use it.

Being part of the antidepressant family, (My Reductil) is not the drug which you might be drinking alcohol during its course of treatment, because both will exert a depressing effect on brain function. So try to be more conservative at birthday parties or celebrations please. The dose of (My Reductil) is 10-15 mg per day by mouth.

One of the most reported side effects experienced by users of (My Reductil), and which - at the same time – are self-limited with continued use or – sometimes – symptomatic treatment, is lack of sleep especially in the first night or two of taking (My Reductil), and the best way to handle that is by taking the pill very early in the morning.

Another very popular side effect, dry mouth, which occurs in more than 10% of users, but it’s nothing to worry about. It may require the user to consume 2-3 litres of water a day, and always carry an extra bottle of water around, but to look at it from another optimistic view, drinking a lot of water daily actually fills the stomach and decreases appetite, so it’s helpful anyway.

There is a famous forum on Yahoo about how good (My Reductil) is as an anti-obesity drug. I’ve been to that forum reading people’s feedback on that drug, and how it really helped most of them with their weight loss battles. Here are some of the remarkable quotes people said after sing that drug: “ With My Reductil, I just have no interest in food “. One guy with inactive thyroid gland said: “ My Reductil is the only thing that helped me “. Another one quoted: “ My Reductil stops you needing to eat. It gets rid of the hunger, but willpower needs to be strong “. A last one: “ Food is not my God anymore “.

There is also one last relation between (My Reductil), blood pressure and headache. That relation needs to be understood by patients in order not to be confused to the extent of quitting treatment for no reason. As I notified earlier, (My Reductil) depends on noradrenaline and serotonin inside the brain to do what it does. As all would know, noradrenaline narrows blood vessels everywhere in the body which contributes to raising the blood pressure alittle, while serotonin, dilates blood vessels, and in the brain, may cause the headaches that (My Reductil) users may experience especially on the first days of treatment. The point is : Don’t just quit (My Reductil) if your blood pressure rises a little bit. You can stop it if the rise in blood pressure is severe ( more than 180/110 ), so that’s why doctors recommend that (My Reductil) users should check their blood pressure closely throughout its use ( twice weekly during the first 3 months ). You shouldn’t worry much about the headache because it goes away later, and as far as your blood pressure is fine, take a panadol or something or the headache and life will go on.

In fact, you should benefit from the 3 months that you start your (My Reductil) in, and not rush losing weight too fast. Losing weight so fast may let you get saggy skin, or let your kidney fall off inside your abdomen due to quick loss of the fat pad attaching it to the wall of the abdomen, so those first 3 months should be used by you wisely. The first month is all about surviving the changes that taking (My Reductil) will have on your life. The second month should be all about trying to establish an eating pattern. The third month should be all about introducing a more extensive exercise program.

The last thing to be mentioned here is that (My Reductil) should not be used in ( severe ) increase in blood pressure. It should not be used at all with peripheral occlusive arterial or coronary heart disease, arrhythmias, enlarged prostate condition, and in severe liver or kidney disease. It shouldn’t also be used to treat obesity of endocrine origin, or those with a major eating disorder or a psychiatric disease. It also shouldn’t be taken together with a tricyclic antidepressant, because both may lead to central nervous system toxicity.